All Journal Articles

Particle Design

Hoe, S., Boraey, M.A., Ivey, J.W., Finlay, W.H., Vehring, R.: Manufacturing and Device Options for the Delivery of Biotherapeutics.  Journal of Aerosol Medicine and Pulmonary Drug Delivery, Accepted for Publication Dec. 2013.

Hoe, S., Semler, D.D., Goudie, A.D., Lynch, K.H., Matinkhoo, S., Finlay, W.H., Dennis, J.J., Vehring, R.: Respirable Bacteriophages for the Treatment of Bacterial Lung Infections.  Journal of Aerosol Medicine and Pulmonary Drug Delivery 26 (6), 317-335, Dec. 2013.

Hoe, S., Ivey, J.W., Boraey, M.A., Shamsaddini-Shahrbabak, A., Javaheri, E., Matinkhoo, S., Finlay, W.H., Vehring, R.: Use of a Fundamental Approach to Spray-Drying Formulation Design to Facilitate the Development of Multi-Component Dry Powder Aerosols for Respiratory Drug Delivery. Pharmaceutical Research, Aug 2013.

Vehring, R., Lechuga-Ballasteros, D., Joshi, V., Noga, B., Dwivedi, S.K.: Cosuspensions of Microcrystals and Engineered Microparticles for Uniform and Efficient Delivery of Respiratory Therapeutics from Pressurized Metered Dose Inhalers. Langmuir 28 (42), 15015-15023, 2012.

Boraey, M.A., Hoe, S., Sharif, H., Miller, D.P., Lechuga-Ballasteros, D., Vehring, R.: Improvement of the Dispersibility of Spray-Dried Budesonide Powders Using Leucine in an Ehtanol-Water Cosolvent System. Powder Technol. (2012), doi: 10.1016/j.powtec.2012.02.047

Lechuga-Ballasteros, D., Noga, B., Vehring, R., Cummings, R.H., Dwivedi, S.K.: Novel Cosuspension Metered-Dose Inhalers for the Combination Therapy of Chronnic Obstructive Pulmonary Disease and Asthma. Future Medicinal Chemistry 3, 1703-1718, 2011.

Matinkhoo, S., Lynch, K.H., Dennis, J.J., Finlay, W.H., Vehring, R.: Spray Dried Respirable Powders Containing Bacteriophages for the Treatment of Pulmonary Infections. J. Pharm Sci., 100, 5197-5205, 2011.

Feng, A.L., Boraey, M.A., Gwin, M.A., Finlay, P.R., Kuehl, P.J., Vehring, R.:Mechanistic models facilitate efficient development of leucine containing microparticles for pulmonary drug delivery. Int. J. Pharmaceutics: 409, 156-163, 2011.

Lechuga-Ballesteros, D., Vehring, R., Dwivedi. S. K.: A New Cosuspension MDI Platform: Scientific Foundations of Mono, Dual and Triple Combination Products. Respiratory Drug Delivery Europe, 2011 , R.N. Dalby, P.R. Byron, J. Peart, J.D. Suman, and P.M. Young (eds), Davis Healthcare International Publishing, River Grove, IL, Vol 1, pp. 101-111, 2011.

Joshi, V., Lechuga-Ballesteros, D., Flynn, B., Vehring, R., Schultz, R., Noga, B., Cummings, R. H., Speck, J. H., Dwivedi. S. K.: Development of Mono, Dual and Triple Combination pMDIs Without Co- formulation Effect. Respiratory Drug Delivery Europe, 2011, R.N. Dalby, P.R. Byron, J. Peart, J.D. Suman, and P.M. Young (eds), Davis Healthcare International Publishing, River Grove, IL, Vol 2, pp. 383-386, 2011.

Boraey, M. A., Matinkhoo, S., Vehring, R.: A New Time and Cost Effective Approach for the Development of Microparticles for Pulmonary Drug Delivery. Respiratory Drug Delivery Europe, 2011 R.N. Dalby, P.R. Byron, J. Peart, J.D. Suman, and P.M. Young (eds), Davis Healthcare International Publishing, River Grove, IL, Vol 2, pp. 473-477, 2011.

Cummings, R. H., Joshi, V., Lechuga-Ballesteros, D., Flynn, B., Vehring, R., Schultz, R., Noga, B., Speck, J. H., Dwivedi, S. K.: Performance Advantages of Pearl Cosuspension Formulations Technology for Manufacturing of Metered-Dose Inhalers. Respiratory Drug Delivery Europe 2011, R.N. Dalby, P.R. Byron, J. Peart, J.D. Suman, and P.M. Young (eds), Davis Healthcare International Publishing, River Grove, IL, Vol 2, pp. 387-390, 2011.

Vehring, R., Miller, D. P., Lechuga-Ballesteros, D.: Pharmaceutical Formulation Comprising a Water-Insoluble Active Agent. US Patent 7,862,834 B2, 2011. Ivey, J., Vehring, R.:The use of modeling in spray drying of emulsions and suspensions accelerates formulation and process development. Computers & Chemical Engineering: 34, 1036, 2010.

Vehring, R. Expert Review: Pharmaceutical Particle Engineering via Spray Drying. Pharm. Res. 25: 999, 2008. Abstract

Lechuga-Ballesteros, D., Charan, C., Stults, C. M., Stevenson, C. L., Miller, D. P., Vehring, R., Tep, V., Kuo, M.-C.: Trileucine Improves Dispersibility, Aerosol Performance and Stability of Spray-Dried Powders for Inhalation. J. Pharm Sci 97: 287, 2008. Abstract

Chan, H.-K., Clark, A. R., Feeley, J. C., Kuo, M.-C., Lehrman, S. R., Pikal-Cleland, K., Miller, D. P., Vehring, R., Lechuga-Ballesteros, D.: Physical Stability of Salmon Calcitonin Spray-Dried Powders for Inhalation. J. Pharm Sci., 93: 792, 2004. Abstract

Lechuga-Ballesteros, D., Charan, C., Liang, Y., Stults, C., Vehring, R., Kuo, M.-C.: Designing Stable and High Performance Respirable Particles of Pharmaceuticals. Respiratory Drug Delivery IX, Vol 2, 565, 2004.

Particle Formation

Boraey, M. A., Vehring, R.: Diffusion Controlled Formation of Microparticles. Journal of Aerosol Science 67, 131-143, 2014.

Shemirani, F.M., Azhdarzadeh, M., Mohammad, T., Fong, J., Church, T.K., Lewis, D.A., Finlay, W.H., Vehring, R.: A Continuous, Monodisperse Propellant Microdroplet Stream as a Model System for Laser Analysis of Mass Transfer in Metered Dose Inhaler Sprays. Respiratory Drug Delivery, 2012, R.N. Dalby, P.R. Byron, J. Peart, J.D. Suman, and P.M. Young (eds), Davis Healthcare International Publishing, River Grove, IL, Vol III, pp. 773-776, 2012.

Vehring, R., Foss, W. R., Lechuga-Ballesteros, D.: Particle Formation in Spray Drying . J. Aerosol Science 38:728, 2007.
#1 Article for J. Aerosol Science, Jul. to Sept. 2007

Moritz, H., Vehring, R., Schweiger, G.: Investigation of the Desorption of Acetylene from Acetone Microdroplets by Raman Spectroscopy. J. Aerosol Sci., 27:S517,1996.

Vehring, R., Moritz, H., Niekamp, D., Heinrich, P., and Schweiger, G.: Linear Raman Spectroscopy on Droplet Chains: A New Experimental Method for the Analysis of Fast Transport Processes and Reactions on Microparticles. Appl. Spectrosc., 49: 1215, 1995. Abstract

Vehring, R., Schweiger, G.: Optical Determination of the Temperature of Transparent Microparticles. Appl. Spectrosc., 46: 25, 1992. Abstract

Vehring, R., Schweiger, G.: Raman Scattering on Liquid Aerosol Particles: Concentration Measurements on Droplet Chains. J. Aerosol Sci., 22: S399, 1991. Abstract

Particle, Powder, and Aerosol Analysis

Azhdarzadeh, M., Olfert, J., Vehring, R., Finlay, W. H. Effect of Electrostatic Charge on Oral-Extrathoracic Deposition for Uniformly Charged Monodisperse Aerosols. Journal of Aerosol Science, http://dx.doi.org/10.1016/j.jaerosci.2013.11.002, 2013.

Golshahi, L., Vehring, R., Noga, M., Finlay, W.H.: In Vitro Deposition of Micrometer-sized Particles in the Oropharyngeal Airways of Children During Tidal Breathing. J Aerosol Sci., 2012, Accepted for Publication

Shemirani, F.M., Hoe, S., Lewis, D., Church, T., Vehring, R., Finlay, W.H. In Vitro Investigation of the Effect of Ambient Humidity on Regional Delivered Dose with Solution and Suspension MDIs. J Aerosol Med. Pulm. Drug Deliv. 26, 1-8, 2012.

Vehring, R., Ivey, J., Williams, L., Joshi, V., Dwivedi, S., Lechuga-Ballastersos, D., : High-Sensitivity Analysis of Crystallinity in Respirable Powders Using Low Frequency Shift Raman Spectroscopy. Respiratory Drug Delivery, 2012, R.N. Dalby, P.R. Byron, J. Peart, J.D. Suman, and P.M. Young (eds), Davis Healthcare International Publishing, River Grove, IL, Vol II, pp. 641-644, 2012.

Shamsaddini-Sharbabak, A., Vehring, R.: The Compression Behavior of Respirable Powders at Different Relative Humidity Measured by a Compressed Bulk Density Tester for Small Sample Masses. Respiratory Drug Delivery, 2012, R.N. Dalby, P.R. Byron, J. Peart, J.D. Suman, and P.M. Young (eds), Davis Healthcare International Publishing, River Grove, IL, Vol III, pp. 777-780, 2012.

Javaheri, E., Vehring, R., Finlay, W.H.: Numerical Modeling of Flocculation and Creaming of Drug Particles Inside the Canister of a Metered Dose Inhaler. Respiratory Drug Delivery, 2012, R.N. Dalby, P.R. Byron, J. Peart, J.D. Suman, and P.M. Young (eds), Davis Healthcare International Publishing, River Grove, IL, Vol III, pp. 769-772, 2012.

Vehring, R.: Red-Excitation Dispersive Raman Spectroscopy is a Suitable Technique for Solid State Analysis of Respirable Pharmaceutical Powders. Appl. Spectrosc., 59: 286, 2005.

Vehring, R., Aardahl, C. L., Schweiger, G., and Davis, E. J.: The Characterization of Fine Particles Originating from an Uncharged Aerosol: Size Dependence and Detection Limits for Raman Analysis. J. Aerosol Sci., 29: 1045, 1998. Abstract

Vehring, R: Linear Raman Spectroscopy on Aqueous Aerosols: Influence of Nonlinear Effects on Detection Limits. J. Aerosol Sci., 29: 65, 1998. Abstract

Vehring, R., Schweiger, G.: Dispersive Raman Spectroscopy on Soot Particles. J. Aerosol Sci., 29: S1251, 1998.

Xu, B., Vehring, R., Schweiger, G.: Identification of the Crystalline Phase of Single Levitated Microparticles. J. Aerosol Sci., 29: S865, 1998.

Vehring, R., Aardahl, C.L., Davis, E.J., Schweiger, G., Covert D.S.: Electrodynamic Trapping and Manipulation of Particle Clouds. Rev.Sci.Instrum., 68: 1, 1997. Abstract

Aardahl, C. L., Vehring, R., Davis, E. J., Schweiger, G., Swanson, B. D.: Trapping Two-Particle Arrays in a Double-Ring Electrodynamic Balance. J. Aerosol Sci., 28: 1491, 1997. Abstract

Aardahl, C. L., Vehring, R., Weber, R., Schweiger, G., Davis, E. J., and Wiedensohler, A.: Electrodynamic Trapping of Aerocolloidal Particles: Experimental and Theoretical Trapping Limits for the Continuum Regime. J. Colloid Interface Sci., 192: 228, 1997. Abstract

Vehring, R., Xu, B., Schweiger, G.: Improved Detection Limits of Linear Raman Spectroscopy on Aerosols. J. Aerosol Sci., 27: S293, 1996.

Borchers, M. A., Esen, C., Vehring, R., Schweiger, G.: Analysis of Coated Microparticles by Raman Confocal Microprobing. J. Aerosol Sci., 27: S543, 1996.

Vehring, R., Schweiger, G.: Raman Thermometry of Aqueous Multicomponent Aerosol Particles. J. Aerosol Sci., 27: S323, 1996.

Moritz, H., Vehring, R., Schweiger, G.: Investigation of the Desorption of Acetylene from Acetone Microdroplets by Raman Spectroscopy. J. Aerosol Sci., 27: S517, 1996.

Vehring, R., Moritz, H., Niekamp, D., Heinrich, P., and Schweiger, G.: Linear Raman Spectroscopy on Droplet Chains: A New Experimental Method for the Analysis of Fast Transport Processes and Reactions on Microparticles. Appl. Spectrosc., 49: 1215, 1995.

Vehring, R., Schweiger, G.: Threshold of Stimulated Raman Scattering in Microdroplets. J. Aerosol Sci., 26: S235, 1995.

Vehring, R., Schweiger, G.: Optical Determination of the Temperature of Transparent Microparticles. Appl. Spectrosc., 46: 25, 1992.

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