A free and open access peer-reviewed online journal since 1998—the first in the field.

Editor: Fakhreddin Jamali

Special Memorial Issue
Antoine Noujaim (1937-2006) 

Guest Editor: Stephen A. McQuarrie and Leonard I. Wiebe

Acknowledgment of Reviewers

Letter from Editors

Contents:

• Review of osmotic pressure driven release of proteins from monolithic devices
  Brian Amsden, CANADA
  PDF version for printing, Page 129

• Phase I study with an autologous tumor cell vaccine for locally advanced or metastatic prostate cancer
  Milton Berger, Fernando T. Kreutz, Jorge L. Horst, Aline C. Baldi, Walter J. Koff, BRAZIL
  PDF version for printing, Page 144
  
  
• Functionalized N-(2-oxyiminoethyl) piperazinyl quinolones as new cytotoxic agents
  Saeed Rajabalian, Alireza Foroumadi, Abbas Shafiee, Saeed Emami, IRAN
  PDF version for printing, Page 153
  
  
• Design and synthesis of new rofecoxib analogs as selective cyclooxygenase-2 (COX-2) inhibitors: Replacement of the methanesulfonyl pharmacophore by a N-acetylsulfonamido bioisostere
  Afshin Zarghi, P. N. Praveen Rao and Edward E. Knaus, CANADA
  PDF version for printing, Page 159
  
  
• Use of a simulated annealing algorithm to fit compartmental models with an application to fractal pharmacokinetics
  Rebeccah E. Marsh, Terence A. Riauka, Steve A. McQuarrie, CANADA
  PDF version for printing, Page 169
  
  
• Molecular imaging agents for clinical positron emission tomography in oncology other than fluorodeoxyglucose (FDG): applications, limitations and potential
  John R. Mercer, CANADA
  PDF version for printing, Page 180
  
  
• Imaging of tumor hypoxia with [124I]IAZA in comparison with [18F]FMISO and [18F]FAZA – First small animal PET results
  Gerald Reischl, Donna S. Dorow, Carleen Cullinane, Andrew Katsifis, Peter Roselt, David Binns, Rodney J. Hicks, GERMANY, AUSTRALIA
  PDF version for printing, Page 203
  
  
• A novel and efficient synthesis of [2-11C]5-fluorouracil for prognosis of cancer chemotherapy
  Koh-ichi Seki, Ken-ichi Nishijima, Yuji Kuge, Nagara Tamaki, Leonard I. Wiebe, and Kazue Ohkura, JAPAN
  PDF version for printing, Page 212
  
  
• Poly(D,L-Lactic-Co-Glycolic Acid) Microsphere delivery of adenovirus for vaccination
  Daqing Wang, Ommoleila Molavi, M. E. Christine Lutsiak, Praveen Elamanchili, Glen S. Kwon, and John Samuel, USA
  PDF version for printing, Page 217
  
  
• Development and validation of a sensitive and spacific HPLC assay of cladribine for pharmacokinetics studies in rats
  Pollen K.F. Yeung, Carrie Ferguson, Ameer Jarrar, Brian King and Mary L. Li, CANADA
  PDF version for printing, Page 231
  
  
• Synthesis, Transportability and hypoxia-selective binding of 1-β-D-(5-Deoxy-5-Fluororibofuranosyl)-2-Nitroimidazole (β-5-FAZR), a configurational isomer of the clinical hypoxia marker, FAZA
  Saeed Emami, Piyush Kumar, Jennifer Yang, Zbigniew Kresolic, Robert Paproski, Carol Cass, Alexander JB McEwan, Leonard I Wiebe, CANADA
  PDF version for printing, Page 237
  
  
• Characterization of a cyclodextrin-oligonucleotide complex by capillary electrophoresis using laser-induced fluorescence
  Jeffrey W. Guthrie, Jang-Ha Ryu, X. Chris Le, and Leonard I. Wiebe, CANADA
  PDF version for printing, Page 246
  
  
• Clinical production, stability studies and PET imaging with 16-α-[18F]fluoroestradiol ([18F]FES) in ER positive breast cancer patients
  Piyush Kumar, John Mercer, Courtney Doerkson, Katia Tonkin and Alexander J.B. McEwan, CANADA
  PDF version for printing, Page 256s
  
  
• [11C]Vinblastine – syntheses and preliminary imaging in cancer patients
  Christoph Solbach, Marianne Patt, M. Reimold, A. Blocher, B. M. Dohmen, R. Bares, K.-P. Zeller, Hans-Juergen Machulla, GERMANY
  PDF version for printing, Page 266s
  
  
• Preparation and evaluation of 211At labelled antineoplastic antibodies
  Almut Walte, Siva Sankar Reddy Sriyapureddy, Zekiye Korkmaz, Doris Krull, Oliver Bolte, Michael Hofmann, Geerd-J. Meyer, Wolfram H. Knapp, GERMANY
  PDF version for printing, Page 277s
  
  
• Synthesis and evaluation of intercalating somatostatin receptor binding peptide conjugates for endoradiotherapy
  Keith Graham, Qin Wang, Regine Garcia Boy, Michael Eisenhut, Uwe Haberkorn and Walter Mier, GERMANY, USA
  PDF version for printing, Page 286s
  
  
• A sensitive assay for the evaluation of cytotoxicity and its pharmacologic modulation in human solid tumor-derived cell lines exposed to cancer-therapeutic agents
  Razmik Mirzayans, Bonnie Andrais, April Scott, Amy Tessier, and David Murray, CANADA
  PDF version for printing, Page 298s
  
  
• Synthetic approaches and bio-distribution studies of [11C]methyl-phenidate
  Marianne Patt, Christoph Solbach, U. Wüllner, A. Blocher, Anke Stahlschmidt, Daniela Gündisch, K.-A. Kovar, Hans-Jürgen Machulla, GERMANY
  PDF version for printing, Page 312s
  
  
• Changing role of somatostatin receptor targeted drugs in NET: Nuclear Medicine’s view
  Vikas Prasad, S. Fetscher and Richard P. Baum, GERMANY
  PDF version for printing, Page 321s
  
  

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