Aerosol Research Lab of Alberta: the Idealized Nasal Inlet

THE ALBERTA IDEALIZED NASAL INLET GEOMETRY

the Alberta Idealized Throat geometry — **Figure 1.**A computer rendered view of the Alberta Idealized Nasal Inlet internal geometry. Anatomical regions of interest are labeled as follows: (1) nasal entrance, (2) turbinates, (3) olfactory region, (4) nasopharynx. ©ARLA

Intranasal drug delivery is widely used for topical treatment of allergic and non-allergic nasal symptoms. The nasal route of administration has also become a prominent alternative route for vaccine delivery and for systemic drug delivery, for example in treating migraine headaches, break-though cancer pain, and opioid overdose emergencies. Across these diverse applications, medicines delivered as nasal sprays or powders must penetrate past the nasal entrance region to deposit in the peripheral nasal cavity, while avoiding deeper penetration to the airways of the lungs. To assist researchers and developers in testing nasal drug products, the Aerosol Research Laboratory of Alberta has recently introduced the Alberta Idealized Nasal Inlet (AINI). Developed based on rigorous numerical simulations and in vitro experiments, the AINI has been shown to accurately mimic regional deposition of nasal sprays that occurs in human nasal airway geometries. The AINI is available for purchase from Copley Scientific Limited for use in the development and characterization of nasal drug products.