Polyethylenimine Coated Bovine Serum Albumin Nanoparticles for Bone-targeting Drug Delivery
Sufeng Zhang, PhD student in Chemical Engineering
Supervisor - Dr. Hasan Uludag
An effective therapeutic agent for treatment of bone diseases is expected to exhibit a high affinity to bone. Unfortunately, current bone therapeutics do not exhibit a high affinity to bone. Hydroxyapatite (HA) is the major component of normal bone. Previous studies have shown that chemical derivatization of proteins with BPs is an effective means to enhance the mineral affinity and improve their therapeutic potential of a wide-range of proteins. The main objective of this study is to develop a new way to conjugate BPs to proteins to impart a bone affinity. We hypothesized that conjugating proteins with a polymer-BP ligand could enhance the mineral affinity and, meanwhile, minimize the possibility of the protein modification that might adversely affect a protein’s bioactivity. The IgG was chosen as a model protein since several therapeutic antibodies are currently pursued for treatment of bone diseases, such as osteoarthritis.
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