Sequence Manipulation Suite:
Protein Isoelectric Point
New version available: Sequence Manipulation Suite 3 (SMS3)
Protein Isoelectric Point calculates the theoretical pI (isoelectric point) for the protein sequence you enter. Use Protein Isoelectric Point when you want to know approximately where on a 2-D gel a particular protein will be found.

Paste the raw sequence or one or more FASTA sequences into the text area below. Input limit is 200,000,000 characters.

  • Add copies of to each sequence.
  • Use pK values from
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