Schulz Laboratory Publications

Following is a select listing of our publications. For more information on these references, please contact us.

2009

VIAPPIANI, S., NICOLESCU, A.C., HOLT, A., SAWICKI, G., CRAWFORD, B.D., LEON, H., VAN MULLIGEN, T., and SCHULZ, R. (2009). Activation of modulation of 72 kDa matrix metalloproteinase-2 by peroxynitrite and glutathione. Biochem Pharmacol 77:826-834.
ALI, M.A.M., and SCHULZ, R. Activation of modulation of 72 kDa matrix metalloproteinase-2 by peroxynitrite and glutathione. Frontiers in Bioscience 14:699-716.
KANDASAMY, A.D., and SCHULZ, R. (2009). Glycogen synthase kinase-3beta is activated by matrix metalloproteinase-2 mediated proteolysis in cardiomyoblasts. Cardiovasc Res 83:698-706.
NICOLESCU, A.C., HOLT, A., KANDASAMY, A.D., PACHER, P., and SCHULZ, R. (2009). Inhibition of matrix metalloproteinase-2 by PARP inhibitors. Biochem Biophys Res Comm387:646-650.
KANDASAMY. A.K., CHOW, A.K., ALI, M.A.M.,and SCHULZ, R. (2009). MMP-2 and myocardial oxidative stress injury: beyond the matrix.. Cardiovasc Res (In Press).

2008

YARAS, N., SARIAHMETOGLU, M., BILGINOGLU, A., AYDEMIR-KOKSOY, A., ONAY-BESIKCI, A., TURAN, B., and SCHULZ, R. (2008) Protective action of doxycycline in diabetic cardiomyopathy in rats. Br J Pharmacol 155:1174-1184.
CENA, J., LALU, M.M., ROSENFELT, R., and SCHULZ, R. (2008). Endothelial dependence of matrix metalloproteinase-mediated vascular hyporeactivity caused by lipopolysaccharide. Eur J Pharmacol 582:116-122.
GUTIERREZ, F.R., LALU, M.M., MARIANO, F., MILANEZI, CM., CENA, J., GERLACH, R.F., SANTOS, J.E., TORRES-DUENAS, D., CUNHA, F., SCHULZ, R. and SILVA, J. (2008). Increased activities of cardiac matrix metalloproteinases (MMP)-2 and MMP-9 are associated with mortality during the acute phase of experimental Trypanosoma cruzi infection. J Infect Dis 197:1468-1476.
LEON, H., BACZKÓ, I., SAWICKI, G., LIGHT, P.E. and SCHULZ, R. (2008). Inhibition of matrix metalloproteinases prevents peroxynitrite-induced contractile dysfunction in the isolated cardiac myocyte. Br J Pharmacol 153:676-683.

2007

DONNINI, S., MONTI, M., RONCONE, R., MORBIDELLI, L., ROCCHIGIANI, M., OLIVIERO. S., CASELLA. L., GIACHETTI, A., SCHULZ, R., and ZICHE, M. (2008). Peroxynitrite inactivates human-tissue inhibitor of metalloproteinase-4. FEBS Lett 582:1135-1140.
SUNG, M.M., SCHULZ, C.G., WANG, W., SAWICKI, G., BAUTISTA-LÓPEZ, N.L., and SCHULZ, R. (2007). Matrix metalloproteinase-2 degrades the cytoskeletal protein α-actinin in peroxynitrite mediated myocardial injury. J Mol Cell Cardiol 43:429-436.
SCHULZ, R., and ALI, M.A.M. (2007). PPARα: essential component to prevent myocardial oxidative stress? Am J Physiol Heart Circ Physiol 293:H11-H12.
CHOW, A.K., CENA, J., and SCHULZ, R. (2007). Acute actions and novel targets of matrix metalloproteinases in the heart and vasculature. Br J Pharmacol 152:189-205.
SARIAHMETOGLU, M., CRAWFORD, B.D., LEON, H., SAWICKA, J., LI, L., BALLERMANN, B.J., HOLMES, C., BERTHIAUME, L.G., HOLT, A., SAWICKI, G., and SCHULZ, R. (2007). Regulation of matrix metalloproteinase-2 activity by phosphorylation. FASEB J 21:2486-2495.
CHOW, A.K., CENA, J., EL-YAZBI, A.F., CRAWFORD, B.D., HOLT, A., CHO, W.J., DANIEL, E.E., and SCHULZ, R. (2007). Caveolin-1 inhibits matrix metalloproteinase-2 activity in the heart. J Mol Cell Cardiol 42:896-901.
SKRZYPIEC-SPRING, M., GROTTHUS, B., SZELAG, A., and SCHULZ, R. (2007). Isolated heart perfusion according to Langendorff - still viable in the new millenium. J Pharmacol Toxicol Meth 55:113-126.
SCHULZ, R. (2007). Intracellular targets of matrix metalloproteinase-2 in cardiac disease - rationale and therapeutic approaches. Ann Rev Pharmacol Toxicol 47:211-242.

2006

LALU, M.M., CENA, J., CHOWDHURY, R., LAM, A., and SCHULZ, R. (2006). Matrix metalloproteinases contribute to endotoxin and interleukin-1 beta induced vascular dysfunction. Br J Pharmacol 149:31-42.
EL-YAZBI, A.F., CHO, W.J., SCHULZ, R., and DANIEL, E.F. (2006). Caveolin-1 knockout alters beta-adrenoceptors function in mouse small intestine. Am J Physiol Gastrointest Liver Physiol 291:G1020-1030.
VIAPPIANI, S., and SCHULZ, R. (2006). Detection of specific nitrotyrosine-modified proteins as a marker of oxidative stress in cardiovascular disease. Am J Physiol Heart Circ Physiol 290:H2167-2168.

2005

CSONT, T., VIAPPIANI, S., SAWICKA, J., SLEE, S., ALTAREJOS, J.Y., BATINIC-HABERLE, I., and SCHULZ, R. (2005). The involvement of superoxide and iNOS-derived NO in cardiac dysfunction induced by pro-inflammatory cytokines. J Mol Cell Cardiol 39:833-840.
SAWICKI, G., LEON, H., SAWICKA, J., SARIAHMETOGLU, M., SCHULZE, C.J., SCOTT, P.G., SZCZESNA-CORDARY, D. and SCHULZ, R. (2005). Degradation of myosin light chain in isolated rat hearts subjected to ischemia-reperfusion injury: a new intracellular target for matrix metalloproteinase-2. Circulation 112:544-552.
PACHER, P, SCHULZ, R., LIAUDET, L., SZABO, C. (2005). Nitrosative stress and pharmacological modulation of heart failure. Trends Pharmacological Sci 6:302-310.
WANG, W., VIAPPIANI, S., SAWICKA, J., and SCHULZ, R. (2005). Inhibition of endogenous nitric oxide in the heart enhances matrix metalloproteinase-2 release. Br J Pharmacol 145:43-49.
LALU, M.M., PASINI, E., SCHULZE, C.J., FERRARI-VIVALDI, M., FERRARI-VIVALDI, G., BACHETTI, T., and SCHULZ, R. (2005) Ischemia-reperfusion injury activates matrix metalloproteinases in the human heart. Eur Heart J 26:27-35.

2004

EGI, K., CONRAD, N.E., KWAN, J., SCHULZE, C., SCHULZ, R., WILDHIRT, S.M. (2004). Inhibition of inducible nitric oxide synthase and superoxide production reduces matrix metalloproteinase-9 activity and restores coronary vasomotor function in rat cardiac allografts. Eur J Cardiothoracic Surg 26:262-269.
LALU, M., CSONT, T., and SCHULZ, R. (2004). Matrix metalloproteinases activities are altered in the heart and plasma during endotoxemia. Crit Care Med 32:1332-1337.
KWAN, J.A., SCHULZE, C.J., WANG, W., LEON, H., SARIAHMETOGLU, M., SUNG, M., SAWICKA, J., SIMS, D.E., and SCHULZ, R. (2004). Matrix metalloproteinase-2 (MMP-2) is present in the nucleus of cardiac myocytes and is capable of cleaving poly (ADP-ribose) polymerase (PARP) in vitro. FASEB J 18: 690-692. Full text article published on-line: www.fasebj.org/cgi/content/full/18/6/690

2003

SCHULZE, C., WANG, W., SUAREZ-PINZON, W.L., SAWICKI, G., and SCHULZ, R. (2003). The imbalance between tissue inhibitor of metalloproteinases-4 and matrix metalloproteinases during acute myocardial ischemia-reperfusion injury. Circulation 107: 2487-2492.
FERDINANDY, P., and SCHULZ, R. (2003). Nitric oxide, superoxide, and peroxynitrite in myocardial ischemia-reperfusion injury and preconditioning. Br J Pharmacol 138: 532-543.
GAO, C.Q., SAWICKI, G., SUAREZ-PINZON, W.L., CSONT, T., WOZNIAK, M., FERDINANDY, P., and SCHULZ, R. (2003). Matrix metalloproteinase-2 mediates cytokine-induced myocardial contractile dysfunction. Cardiovasc Res 57: 426-433.
LALU, M.M., GAO, C.Q., and SCHULZ, R. (2003). Matrix metalloproteinases inhibitors attenuate endotoxemia induced cardiac dysfunction: a potential role for MMP-9. Mol Cell Biochem, 251: 61-66.

2002

LALU, M.M., WANG. W., and SCHULZ, R. (2002). Peroxynitrite in myocardial ischemia-reperfusion injury. Heart Failure Reviews 7: 359-369.
KHADOUR, F.H., PANAS, D., FERDINANDY, P., SCHULZE, C., CSONT, T., LALU, M.M., WILDHIRT, S.M. and SCHULZ, R. (2002). Enhanced NO and superoxide generation in dysfunctional hearts from endotoxemic rats. Am J Physiol 283: H1108-H1115.
WANG, W., SCHULZE, C.J., SUAREZ-PINZON, W.L., DYCK, J.R.B., SAWICKI, G. and SCHULZ, R. (2002). Intracellular action of matrix metalloproteinase-2 accounts for acute myocardial ischemia and reperfusion injury. Circulation 106: 1543-1549.
MUNGRUE, I.N., GROS, R., YOU, X., PIRANI, A., AZAD, A., CSONT, T., SCHULZ, R., BUTANY, J., STEWART, D.J. and HUSAIN, M. (2002). Cardiomyocyte over- expression of iNOS in mice results in peroxynitrite generation, heart block and sudden death. J Clin Invest 109: 735-743.
WANG, W., SAWICKI, G., and SCHULZ, R. (2002). Peroxynitrite-induced myocardial injury is mediated through matrix metalloproteinase-2. Cardiovasc Res 53: 165-174.

2001

FERDINANDY, P., and SCHULZ, R. (2001). Peroxynitrite: toxic or protective in the heart? Circ Res 88: e12 - e13.
FERDINANDY, P., and SCHULZ, R. (2001). Inhibition of peroxynitrite-induced dityrosine formation with oxidized and reduced thiols, NO donors, and purine-derivatives. Antioxidants Redox Signaling 3: 165-171.

2000

CHEUNG, P-Y., WANG, W., and SCHULZ, R. (2000). Glutathione protects against myocardial ischemia-reperfusion injury by detoxifying peroxynitrite. J Mol Cell Cardiol 32: 1669-1678.
FERDINANDY, P., DANIEL, H., AMBRUS, I., ROTHERY, R., and SCHULZ, R. (2000). Peroxynitrite is a major contributor to cytokine-induced myocardial contractile failure in rat hearts. Circ Res 87: 241-247.
TATCHUM-TALOM, R., SCHULZ, R., McNEILL, J.R., and KHADOUR, F. (2000). Upregulation of neuronal nitric oxide synthase in skeletal muscle by swim training. Am J Physiol 279: H1757-H1766.
CHEUNG, P-Y., SAWICKI, G., WOZNIAK, M., WANG, W., RADOMSKI, M.W., and SCHULZ, R. (2000). Matrix metalloproteinase-2 contributes to ischemia-reperfusion injury in the heart. Circulation 101: 1833-1839.

Dr. Richard Schulz, Ph.D.

University of Alberta
Professor, Departments of Pediatrics and Pharmacology
AHFMR Scientist
Faculty of Medicine & Dentistry
University of Alberta