Dr. Bruce Ritchie MD, FRCPC
Division of Hematology, Dept. of Medicine
University of Alberta
My laboratory is interested in the
biology of coagulation and approaches to treat coagulation disoders.
In the past we have studied in detail the molecular changes causing
coagulation protein deficiencies, focussing on
hemophilia B, factor VII deficiency, and antithrombin deficiency. At
the same time we investigated the expression of recombinant
coagulation factors and their domains in mammalian cells tissue
culture to do structure function studies and to use as
probes of the biology of coagulation.
The coagulation of blood is a complex process involving a variety of cells, proteins, carbohydrates and phospholipids. Although the function and structure of many of the key proteins is understood in detail, their interactions remain hazy. We have tried to dissect mechanisms by which these components interact, using the calcium binding protein calreticulin as a probe.
Recently, we have designed a series of novel strategies for banking of biologic samples from patients who require treatment with pooled blood products. This work involves the developoment of open source software, using CaTissue as a model, and novel, cable driven, robots for sample placment and picking.
Ritchie DBC, Robertson DL, MacGillivray RTA. Factor IX gene structure and protein synthesis: in Recombinant Technology in Hemostasis & Thrombosis, Hoyer LW and Drohan WN Eds. NY, Plenum Press, 1991.
Peer Reviewed Publications
Cicardi M, Aleena Banerji, Francisco Bracho, Alejandro Malbrán, Bernd Rosenkranz, Marc Riedl Konrad Bork, The Fast-1 and Fast-2 Investigators. Icatibant a Novel Bradykinin-B2 Receptor Antagonist, is effective in the Treatment of Acute Attacks in Patients with Hereditary Angioedema. (NEJM submitted)
Elias AL, Cooper AM, Gao Y, Ritchie B, Buriak JM. Stability of Gold Nanoparticles in Blood Serum (submitted)
Craig TJ, Levy RJ, Wasserman RL, Bewtra AK, Hurewitz D, Obtu?owicz K, Reshef A, Ritchie B, Moldovan D, Shirov T, Grivcheva-Panovska V, Kiessling P, Keinecke H-O, Bernstein JA. Efficacy of Human C1-Esterase Inhibitor (C1-INH) Concentrate Compared to Placebo in Patients with Acute Abdominal or Facial HAE Attacks. J Allergy Clin Immunol. 2009 Oct;124(4):801-8. Epub 2009 Sep 19.PMID: 19767078
Bowen T, Cicardi M, Bork K, Zuraw B, Frank M, Ritchie B, Farkas H, Varga L, Zingale LC, Binkley K, Wagner E, Adomaitis P, Brosz K, Burnham J, Warrington R, Kalicinsky C, Mace S, McCusker C, Schellenberg R, Celeste L, Hebert J, Valentine K, Poon MC, Serushago B, Neurath D, Yang W, Lacuesta G, Issekutz A, Hamed A, Kamra P, Dean J, Kanani A, Stark D, Rivard GE, Leith E, Tsai E, Waserman S, Keith PK, Page D, Marchesin S, Longhurst HJ, Kreuz W, Rusicke E, Martinez-Saguer I, Aygoren-Pursun E, Harmat G, Fust G, Li H, Bouillet L, Caballero T, Moldovan D, Spath PJ, Smith-Foltz S, Nagy I, Nielsen EW, Bucher C, Nordenfelt P, Xiang ZY. Hereditary angiodema: a current state-of-the-art review, VII: Canadian Hungarian 2007 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema. Annals of Allergy Asthma and Immunology 2008;100, Supp 2:30-40. PubMed 18220150
Basak A Clements, Vanessa Incani, Cezary Kucharski, Afsaneh Lavasanifar, Bruce Ritchie, Hasan Uludag. A comparative evaluation of Poly-L-Lysinne-Palmitic acid and lipofectamine 2000 TM for plasmid delivery to bone marrow stromal cells. Biomaterials, 2007; 28:4693-4704. PubMed 17686514
Belletrutti M, Ali K, Barnard D, Blanchette V, Chan A, David M, Luke B, Price V, Ritchie B and Wu J. Chronic Immune Thrombocytopenic Purpura in Children: A Survey of the Canadian Experience. Journal of Pediatric Hematology/Oncology 2007; 29:95-100. PubMed 17279005
Bungard TJ, Archer SL, Hamilton P, Ritchie B, Tymchak W, Tsuyuki. Bringing the Benefits of Anticoagulation Services to the Community. Canadian Pharmacy Journal 2006;139: 58-64. PubMed
Acan-Clements B, Bai J, Kucharski C, Farrell L-L, Lavasanifar A, Ritchie B, Ghahary A, Uludag H. RGD Conjugation to Polyethyleneimine Does Not Improve DNA Delivery to Bone Marrow Stromal Cells. 2006 Biomacromolecules PubMed 16677029.
Ludlam CA, Powderly W, Bozzette S, Diamond M, Koerper MA, Kulkarni R, Ritchie B, Siegel J, Simmonds P, Stanley S, Tapper M, von Depka M. Clinical Perspectives of Emerging Pathogens in Bleeding Disorders. Lancet 2006; 367(9506): 252-261 PubMed 16427495.
Al-Saif F, Al-Masloom A, Johnson MA, Bain VG, Sandha GS, Ritchie DB, Shapiro AM. Automimmune pancreatitis with autoimmune hemolytic anemia. Pancreas. 2006 Oct;33(3):316-7. PMID: 17003658
Majeski C, Ritchie, B, Giuffre M, Lauzon G. Pincer Nail Deformity Associated with Systemic Lupus Erythematosus. J Cutan Med Surg, Oct 6. 2005 PubMed 16208437
Jiang Bai, Bascedilak Açan, Aziz Ghahary, Bruce Ritchie, Vishwa Somayaji, Hasan Uludag. Poly(ethyleneimine)/arginine-glycine-aspartic acid conjugates prepared with N-succinimidyl 3-(2-pyridyldithio)propionate: An investigation of peptide coupling and conjugate stability. Journal of Polymer Science Part A: Polymer Chemistry 42(23): 6143-6156, 2004 Dec. DOI: 10.1002/pola.20472 PubMed
Tom Bowen MD, Marco Cicardi MD (on behalf of PREHAEAT), Henriette Farkas, Konrad Bork, Wolfhart Kreuz, Lorenza Zingale, Lilian Varga, Inmaculada Martinez-Saguer, Emel Aygören-Pürsün, Karen Binkley, Bruce Zuraw, Alvin Davis III, Jacques Hebert, Bruce Ritchie, Jeanne Burnham, Anthony Castaldo, Alejandra Menendez, Istvan Nagy, George Harmat, Christoph Bucher, Gina Lacuesta, Andrew Issekutz, Richard Warrington MB, William Yang, John Dean, Amin Kanani, Donald Stark MD, Christine McCusker, Eric Wagner, Georges-Etienne Rivard MD, Eric Leith MD, Ellie Tsai MD, Michael MacSween, John Lyanga MD, Bazir Serushago, Art Leznoff, Susan Waserman MD, and Jean de Serres MD. Canadian 2003 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema. J Allergy Clin Immun. Volume 114, Issue 3, Pages 463-712 (2004) PubMed 15356569
Webster D. Ritchie B. Mant MJ. Prompt response to rituximab of severe hemolytic anemia with both cold and warm autoantibodies. American Journal of Hematology. 75(4):258-9, 2004 Apr. PubMed 15054824
Bowen T, Hebert J, Ritchie B, Burnham J, MacSween M, Warrington R, Yang W, Issekutz A, Karitsiotis N, McCombine N, Giulivi T. Management of hereditary angioedema: a Canadian approach. Transfusion and Apheresis Science 2003, 29: 205-14. PubMed 14572811
Ritchie B. Tissue Archives To Track Blood Borne Pathogens in People Receiving Blood Products. Transfusion and Apheresis Science. 2003, 29: 269-74. PubMed 14572820
Ritchie B. Protease Inhibitors in the Treatment of Hereditary Angioedema. Transfusion and Apheresis Science 2003, 29: 259-67. PubMed 14572819
Lee D H, Walker I R, Teitel J, Poon M-C, Ritchie B, Akabutu J, Sinclair G D, Pai M, Wu J, Reddy S, Carter C, Growe G, Lillicrap D, Lam M, Blajchman M A. Effect Of The Factor V Leiden Mutation On The Clinical Expression Of Severe Hemophilia A., Thrombosis and Haemostasis 2000, 83:387-91. PubMed 10744141
Mant MJ, Turner AR, Ritchie BC, Larratt LM. Splenectomy during partial remission in thrombotic thrombocytopenic purpura with prolonged plasma exchange dependency. American Journal of Hematology. 62(1):56-7, 1999 Sep. PubMed 10467278
Sanders ML, Jaworski D, Wormser GP, Nadelman RB, Scott AL, Glass GE, Raha S, Ritchie B, Schwartz BS. Antibody Levels To Recombinant Tick Calreticulin Increase in Humans After Exposure to Ixodes Scapularis (Say) And Are Correlated With Tick Engorgment Indices. American Journal of Epidemiology 1999;149:777-784. PubMed 10206628
Teitel JM, Card R, Strawczynski and the Association of Hemophilia Clinic Directors of Canada Laboratory and Clinical Markers of HIV Infection in a National Haemophilia Cohort Treated with Recombinant Factor VIII Concentrate. Hemophilia 1998, 4, 731-8. PubMed 9873879
Schulman S, d'Oiron R, Martinowitz U, Pasi J, Briquel M-E, Mauser-Bunschoten E, Morfini M, Ritchie B, Goudemand J, Lloyd J, McPherson J, Peerlinck K, Petrini P, Tusell J. Experiences with continuous infusion of recombinant activated factor VII. Blood, Coagulation and Fibrinolysis supplement 1998, 9 (suppl 1):S97-101. PubMed 9819037
Sanders ML, Jaworski D, Sanchez JL, DeFraites RF, Scott AL, Glass GE, Raha S, Ritchie B, Needham GR, Schwartz BS. Antibody To A cDNA-Derived Calreticulin Protein From Amblyomma Americanum Is A Biomarker Of Tick Exposure In Humans. American Journal of Trop Med Hygiene, 59(2), 1998, 279-285. PubMed 9715947
Dai E, Stewart M, Ritchie B, Mesaeli N, Raha S, Kolodziejczyk D, Lundstrom-Hobman M, Liu LY, Etches W, Nation N, Michalak M, Lucas A. Calreticulin, a Calcium Binding Protein with Anti-thrombotic Activity, Prevents Intimal Hyperplasia after Arterial Injury. Arteriosclerosis, Thrombosis & Vascular Biology 1997;17:2359-68. PubMed 9409202
Gilchrist M, MacDonald AJ, Neverova I, Ritchie B, Befus AD. Optimization of the Isolation and Effective Use of mRNA from Rat Mast Cells. J Immunol Methods 1997;201:207-14. PubMed 9050942
Walker I, Pai M, Akabutu J, Ritchie B et al. The Canadian Hemophilia Registry as the basis for a national system for monitoring the use of factor concentrates. Transfusion 1995;35:548-55. PubMed 7631385
Lee C, Ritchie DBC, Lin CC. A tandemly repetitive, centromeric DNA sequence from the Canadian woodland caribou (Rangifer tarandus caribou): its conservation and evolution in several deer species. Chromosome Research 1994, 2;293-306. PubMed 7921645
Ritchie B, Woodman RC, Poon M-C. Deep Vein Thrombosis in Hemophilia A. American Journal of Medicine. American Journal of Medicine 1992;93:699-700. PubMed 1466369
Schreiber WE, Jamani A, Ritchie B. Detection of a T/C polymorphism in the porphobilinogen deaminase gene using PCR amplification of specific alleles. Clin Chem 1992;38:2153-5. PubMed 1356661
Toguchida J, Yamaguchi T, Ritchie B, Beauchamp RL, Dayton SH, Herrera G E, Yamamuro T, Kotoura Y, Sasaki MS, Little JB, Weichselbaum RR, Ishizaki K, & Yandell DW. Mutation spectrum of the p53 gene in bone and soft-tissue sarcomas. Cancer Res 1992;52:6194-9. PubMed 1423262
Ritchie BC, Jones AR. Alpha interferon and hairy cell leukemia. New Zealand Med J 1986;99:68-9. PubMed 3456118
Ritchie DBC, Jennings LC, Lynn KL, Bailey RR, Cook HB. Clostridium difficile - associated colitis: cross infection in predisposed patients with renal failure. New Zealand Med J 1982;95:265-7. PubMed 6953368
Collaborative Papers with the Association of Hemophilia Clinic Directors of Canada (AHCDC):
Arnold DM, Julian JA, Walker IR for the Association of Hemophlia Clinic Directors of Canada (AHCDC). Mortality rates and Causes of Death Among All HIV-Positive Individuals with Hemophili in Canada over Twenty-one Years of Follow up. Blood 2006 DOI 10.1182/BLOOD-2005-11-4407 PubMed 16551974
A.R. Giles, B. Verbruggen, G.E. Rivard, J. Teitel, I. Walker and the Association of Hemophilia Centre Directors of Canada on behalf of the SSC Scientific Subcommittee on Factor VIII and Factor IX. A Detailed Comparison of the Performance of the Standard versus the Nijmegen Modification of the Bethesda Assay in Detecting Factor VIII:C Inhibitors in the Haemophilia A Population of Canada. Thrombosis and Haemostasis Vol. 79(4), page 872.-5, 1998. PubMed 9569207
AHCDC (Association of Hemophilia Clinic Directors of Canada) Hemophilia And Von Willebrands disease: 2. Management. CMAJ 1995;153:147-57. PubMed 7600466
AHCDC (Association of Hemophilia Clinic Directors of Canada) Hemophilia And Von Willebrands disease: 1. Diagnosis, comprehensive care and assessment. CMAJ 1995;153:19-25. PubMed 7796372
Blanchette V, Walker I, Gill P, Adams M, Roberts R, Inwood M, Canadian Hemophilia Clinic Directors Group. Hepatitis C Infection in patients with Hemophilia. Results of a National Survey. Transfusion Medicine Reviews. 1994;8:210-7. PubMed 8081082
Walker IR, Julian J, and the AHCDC (Association of Hemophilia Clinic Directors of Canada) Causes of Death in Canadians with Hemophilia 1980-94. Hemophilia 1998;4:714-20. PubMed 9873876
Canadian Hemophilia Clinic Directors Group. Effect of using safer blood products on prevalence of HIV infection in hemophilic Canadians. Brit Med J 1993;306:306-7. PubMed 1676860
Fast 3: A Phase III Randomized Double-blind, Placebo-controlled Multicenter Study of Icatibant for Subcutaneous Injection in Patients with Acute Attacks of Hereditary Angioedema (HAE), Ritchie B, Canadian Society of Allergy and Clinical Immunology Oct 2009.
Tinmouth A, Blanchette V, Devaraj R, Ritchie B, van den Hoef G, Barnes DG. A Canadian prospective, observational, open-label, pharmacovigilance study to assess the safety of Humate-P® injection volume reduced (ivr) in patients with von Willebrand disease. Submitted, American Society of Hematology Dec. 2009.
J. Mahlangu, T. Andreeva, D. Macfarlane, M. Reding, C. Walsh, B. Ritchie, N. Ewing, C. Kessler, C. Kempton, E. Libby, N. Zozulya, A. Shapiro, J. St-Louis, I. Warrier, K. Hoots, R. Gruppo. A Phase II Open-Label Study Evaluating Hemostatic Activity, Pharmacokinetics and Safety of Recombinant Porcine Factor VIII (rpFVIII, OBI-1) in Hemophilia A Patients with Alloantibody Inhibitors Directed Against Human FVIII (hFVIII) Presented at the American Society of Hematology Dec. 2007
W Lumry, B Ritchie, T Beck and J Morrison. Interim Results of EDEMA2, a Multicenter, Open-label, Repeat-dosing Study of Intravenous and Subcutaneous Administration of Ecallantide (DX-88) in Hereditary Angioedema. Journal of Allergy and Clinical Immunology. February 2006, Vol. 117, Issue 2, Supplement 1 AAAAI Annual Meeting 2006
Basak Açan, Jiang Bai, Cezary Kucharski, Laura-Lee Farrell, Afsaneh Lavasanifar, Bruce Ritchie, Aziz Ghahary, Hasan Uludag. Cationic Polymers as alternatives to viral gene delivery: RGD-conjugation to cationic polymers does not improve dna delivery. Presented at the Canadian Biomaterials Society meeting at Waterloo.
Syed Kaiser Ali, Mark Belletruti, Dorothy Barnard, Anthony Chan, Michele David, Brian Luke, Victoria Price, Bruce Ritchie and John Wu. A Ten Year Survey Of Chronic Immune Thrombocytopenic Purpura in Canadian Children, 1984-2003: Report of the Canadian Chronic ITP Working Group. Blood 2004, Volume 104, Issue 11
Stobart K, Crumley E, Sol T, Ritchie B. A Web-based Systematic Approach to Search the Health Science Literature for Articles Concerning von Willebrand's Disease. American Society of Hematology Meeting Dec 2003.
Stobart K, Crumley E, Sol T, Ritchie B. Developing a web-based systematic approach to search the health science literature for articles concerning von Willebrand's Disorder. Canadian Cochrane Network Meeting in November 2003.
DBC Ritchie, W McClure, WS Etches, JJ Akabutu, and L Larratt. Continuous Infusion of FVII following trauma - Labroatory arssessment and stability of FVII Blood 1998, vol 92, supplement , # 3446.
Stang L, McClure W, Stewart MW, Etches W, Akabutu JJ, and Ritchie DBC. Laboratory Assessment of rFVIIa Levels -Disagreement Between Clot Based FVII and FVIIa Assays During Continuous Infusion of rFVIIa. Blood 1998, vol 92, supplement #2279.
Edmond Ryan, Bruce Ritchie, Lenka Pospisil. A novel hypothesis for the pathogenesis of diabetic neuropathy. presented at the Canadain Diabetes Association meeting Oct, 1998, Calgary AB.
MA Hamilton, AR Morgan, A Severini, Bruce Ritchie. Development Of An Assay To Measure Heparin Levels In Blood. Resident Research Day, University of Alberta, April, 1998.
Neesh Pannu, Syamal Raha, Bruce Ritchie. Probing The Structure & Function of Lambda Repressor. Resident Research Day, University of Alberta, April, 1998.
Anthony Woods, Syamal Raha, Michael Stewart, Bruce Ritchie. Whole Blood Clotting Assay To Screen For Anticoagulant Activity. Resident Research Day, University of Alberta, April, 1998.
McClure W, Ritchie DBC, Lees G, Procyshyn G, Akabutu A. Lack of Infection in the Use of Porta-caths in Hemophilia. Haemophilia 1998, vol 4, 63
DBC Ritchie, W McClure, MW Stewart, WS Etches, B Fenyves, JJ Akabutu and PR Boucher. Elective Joint Replacement In Hemophilic Men With High Titre Factor VIII Inhibitors. Haemophilia 1998, vol 4, 340
Raha, SK, Stewart M, Ritchie BC, Calreticulin Inhibits Thrombin And Blocks The Inhibition Of Factor Xa By Heparin. 1998 European Hematology Association Meeting, Jul 1998, Amsterdam, Netherlands. British Journal of Hematology 1998, 102, no 1.
Mant MJ, Turner AR, Ritchie BC, Larratt LM. Splenectomy During Partial Remission in Patients With Thrombotic Microangiopathy (TMA) With Prolonged Plasma Exchange Dependency. Blood 1997, Vol 90, supplement.
Schulman S, Martinowitz U, Pasi J, Mauser-Bunschoten E, Morfini M, Goudemand J, Lloyd J, McPherson J, Peerlinck K, Petrini P, Ritchie B, Tusell J. Experiences with continuous infusion of recombinant activated factor VII. presented at rFVII symposium, Copenhagen, Denmark, Sept 1997.
Syamal K. Raha, Mike Stewart, Bruce C. Ritchie. Calreticulin Is A Potent Inhibitor Of Thrombin, Only In The Presence Of Platelets. Clinical Invest. Med. 1997;20:S29.
Mant MJ, Turner AR, Ritchie BC, Larratt LM. Splenectomy as definitive treatment for patients (pts) with thrombotic microangiopathy (TMA) who remain plasmaphoresis dependent after 30 days, including success in a patient with TMA due to mitomycin C. Thrombosis and Haemostasis 1997 Supplement, PS1314.
Boshkov LK, Ritchie DBC, Dasgupta M, Etches W, Stewart M. Detection of IgM VWF Inhibitor Associated with Clinical Bleeding. Blood 1996, 88 supp 1:3016.
SP Reddy, CM Upsahw, MG King, WS Etches, RM Dorward, L-J Chang, D Robinson and DBC Ritchie. Gene Therapy Approaches To Hemophilia A. Twenty-Ninth Annual Students Research Day, Oct 5, 1996.
MacDonald AJ, Gilchrist M, Ritchie DBC, Duszyk M, Befus AD. Interferon-c Induces mRNA for a Putative Chloride Channel and Concurrent Chloride Influx in Rat Mast Cells. Canadian Thoracic Society Meeting Oct25-7, 1996.
CM Upsahw, SP Reddy, MG King, WS Etches, RM Dorward, L-J Chang, D Robinson and DBC Ritchie. Gene Therapy Approaches To Hemophilia A. Hemophilia 1996;2:351. Hemophilia 1996;2 supp 1:351.
DBC Ritchie, DST Kwok, T. Byers, EJ Boffa, LM Larratt, WS Etches, JK McNern, A Rasouli-Nia, and BJ Clarke. Sequence Changes In The Factor VII Gene - FVII El Salvador And Two New Polymorphisms. Hemophilia 1996;2 supp 1:250.
Lee DH, Walker IR, Poon MC, Rivard G, Teitel J, Ritchie B, Akabutu J, Sinclair GD, Pai M, Wu J, Reddy S, Crowther MA, Blachman MA. Factor V Leiden Is Not Protective in Severe Hemophilia. Hemophilia 1996;2 supp 1:178.
Liu D, Ritchie BC, Ryan EA. Increased Expression of A Novel Gene in Muscle of Offspring of diabetic rats identified by mRNA differential display. Diabetes, 1996;45:58A. Diabetes, 1996;45 supp2: 58A.
SK Raha, MW Stewart, M Michalak, WS Etches, A Lucas and DBC Ritchie. Calreticulin Prolongs Whole Blood Clotting Time Using The St4 Analyzer. Britsih Journal of Hematology, 1996;93:20.
SK Raha, MW Stewart, M Michalak, WS Etches, A Lucas, DC Jaworski and DBC Ritchie. Calreticulin Prolongs Whole Blood Clotting Time Via A Platelet Mediated Pathway. International Workshop on Calreticulin, Villa Olmo, Italy April 29-30, 1996.
Duszyk M, Fang D, Parker E, Ritchie DBC, Kamosinska B, Man SFP.. Synthetic Peptides As Model System For The Pore Structure Of An Epithelial Sodium Channel. Prog. Biophys Mol Biol, 1996; 65 supp 1:106.
Ritchie B. Gene therapy approaches to Hemophilia A. Alberta Gene Therapy Conference. Nov 23, 1995. Red Deer, Alberta.
Lucas A, Dai E, Liu L, Ritchie B, Nasrin Mesali, Lundstrom-Hobman M, Stewart M, Yan W, Boshkov L, and Michalak M. Calreticulin, A Unique Calcium Binding Protein, Regulates Vascular Inflammatory and Thrombotic Responses to Arterial Injury. Circulation, 1995;92:f111.
McMahon A, Raha S K, Mulvey G, Armstrong G and Ritchie DBC. Cyclosporine induced cytotoxicity and platelet binding to endothelial cells. Sixth Annual Residents Research Day, Dept of Internal Medicine, University of Alberta May 25, 1995. 1995 resident research award
Fekete R, Ritchie DBC. Characterization of a mutation in the glucokinase gene associated with type II diabetes mellitus. Presented at the Faculty of Medicine student research days, Univ of Alberta, 1993. 1993 student research award from the Medical Alumni Association
Byers T, Kwok D, Ritchie DBC. A new polymorphism in the FVII gene. Presented at the Faculty of Medicine student research days, Univ of Alberta, 1993.
Boffa EJ, Ritchie DBC. Development of a novel protease assay. Presented at the Faculty of Medicine student research days, Univ of Alberta, 1993. 1993 Honorable Mention award from the Medical Alumni Association
Boffa EJ, DST Kwok, LM Larratt, W Etches, JK McNern, Ritchie DBC. A new polymorphism in the FVII gene. Presented at the Faculty of Medicine student research days, Univ of Alberta, 1992.
Schreiber WE, Jamani A, Ritchie B. Detection of a T/C polymorphism in the porphobilinogen deaminase gene using PCR amplification with allele-specific primers. presented at the American Association for Clinical Chemistry 1992 meeting.
Schreiber W, Jamani A, Adomat S, Horsman BD, and Ritchie DBC. Molecualar analysis of the porphobilinogen deaminase gene in a patient with acute intermittent porphyria. presented at the 1991 Canadian Society of Clinical Chemists meeting , Montreal, June 2-6, 1991.
Matthewson BE, Ritchie DBC, and Coupland RW. Detection of carriers and prenatal diagnosis of hemophilia in a hospital laboratory. presented at the Canadian Society of Laboratory Technologists 1991 National Congress, Montreal, Quebec, May 26-31, 1991.
Tam BM, MacGillivray RTA, Ritchie DBC. Analysis of mutations causing hemophilia B in western Canada. Thrombosis and Haemostasis 1991; 65:968.
Ritchie DBC and MacGillivray RTA. Expression of recombinant human factor XII in mammalian cells. presented at the International Symposium on Biotechnology of Plasma Proteins: haemostasis, thrombosis and iron proteins, Florence, Italy, April 9-11, 1990.
Ritchie DBC, Tam BM, MacGillivray RTA. A novel mutation of the facto IX gene in hemophilia B identified using the polymerase chain reaction. presented at the Heritage Days meeting of the Alberta Heritage Foundation for Medical Research, Dec 1,1989, Calgary, Alberta, Canada.
Ritchie B, Berman-Wong E, Herbut B, Dawson D, Snider C, Smith L, England B, Cassol S, Bowen T. Comparison of three methods for detection of alloimmunization following random donor platelet transfusion. Clinical and Investigative Medicine 1986;9:R504. Presented at the Royal College of Physicians and Surgeons of Canada meeting, September 21-25, 1986, Toronto, Ont, Canada.
Bowen T, Berman-Wong E, Snider C, Herbut B, Smith L, England B, Ritchie B. Alloimmunization following random donor platelet transfusion determined by three antibody detection techniques. Clinical Research 1985;34:74A.
Collaborative Abstracts as part of the Association of Hemophilia Clinic Directors of Canada:
Poon MC and the Canadian Factor IX Study Group. No Inhibitors After Administration of Factor IX Concentrate, Immunine. Thrombosis and Haemostasis 1997 Supplement, PS220.
Poon MC and the Canadian Factor IX Study Group. Results From An International Efficacy Study of Factor IX Concentrate, Immunine. Thrombosis and Haemostasis 1997, Supplement PS219.
I Walker and Association of Hemophilia Clinic Directors. Causes of Death in Canadians With Hemophilia 1980-95. Hemophilia 1996;2 supp 1:253.
Walker I, Association of Hemophilia Clinic Directors of Canada. Causes of Death in Canadians with Hemophilia 1980-93. National Hemophilia Foundation Conference. Liver disease in Hemophilia: New direction in Diagnosis, Management and Treatment. Atlanta, Georgia, March 3-5, 1995.
Walker IR, and the Canadian Hemophilia Clinic Directors Group. Canadian Hemophilia Registry (CHR) - Update and Assessment of Completeness. XXI International Congress of the World Federation of Hemophilia, Mexico City, Mexico. April 1994.
Inwood MJ, Clegg E, Carter S. on behalf of the Canadian Hemophilia Centre Directors and Nurse Coordinators Group. A survey of Central Venous Access Devices (CVAD) in a Canadian Hemophilia Population. Presented at the congress of the World Hemophilia Federation, Mexico City, April 24-9, 1994.
Walker IR, and the Canadian Hemophilia Clinic Directors Group. HIV in Canadians with Hemophilia: Prevalence, Mortality, and the Impact of Safer Factor Concentrates XX Congress of the World Federation of Hemophilia, Athens, Greece, October 1992.
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