PRINCIPAL INVESTIGATOR

Michael Woodside


Professor, University of Alberta
iCORE Chair in Biophysics

NINT 2-019 or CCIS 3-205
(780) 641-1695
fax:(780) 641-1601
Technicians:
Feng Wang
NINT 2-033B

(780) 641-1696



I characterize RNA/DNA aptamers, and isolate and characterize inorganic metal binding peptide by phage display. I provide technical support on molecular biology/ biochemical methods and techniques, as well as provide DNA and RNA samples for different projects.

Craig Garen
NINT 2-072A



My research includes using molecular biology and protein biochemistry techniques to aid in the biophysical characterization of protein misfolding and aggregation in neurodegenerative disorders. This includes human superoxide dismutase (amyotrophic lateral sclerosis) and prion protein (spongiform encephalopathies). 
Russell Kirchner
As a research technician I assist Woodside group members with their projects and carry out a variety of tasks associated with the biophysical instrumentation.
Research Associates:
Krishna Neupane
NINT 2-084B


Currently, I am studying misfolding and aggregation of the protein α-synuclein at the single molecule level using optical tweezers.

Postdoctoral Fellows:
Supratik Sen Mojumdar
NINT 2-021A

780-641-1696


I am interested in identifying the folding-misfolding trajectories of super-oxide dismutase 1 (SOD1) protein using single molecule force spectroscopy (optical tweezers). 
Chunhua Dong
NINT 2-035F

780-248-1457 (lab)

780-641-1722 (office)



My research interests include:
-Quantitative c
haracterization with s
canning probe microscopies for the study at nanoscale of nanomaterials and nanosystems: magnetic properties for bio-applications.
-The study of oligomer formation and mechanism during the progression of Parkinson's Disease.
Uttam Anand
NINT 2-033C


I am working with Prion proteins using single molecule force spectroscopy (optical tweezers) to understand and correlate various factors that provide protection against misfolding and disease. This involves focusing on sequence effects, protective mutations and chemical chaperones that have anti-prion activity.
Rafayel Petrosyan
In prion diseases, the protein PrP takes on an incorrect shape that is infectious and collects in clumps (aggregates). A number of potential drug molecules that bind to PrP have been found to give some form of protection against disease, however the mechanisms of protection are poorly understood. My main projects aim is to find out how these molecules protect against disease that would help to develop new or improved drugs to treat prion diseases.
Lindsay Shearer
My research focuses on the study of oligomeric constructs of alpha-synuclein in the presence of inhibitors of aggregation in solution for a Parkinson's disease study.  This research is accomplished via fluorescence correlation spectroscopy (FCS) and image correlation spectroscopy (ICS) techniques.
Meng Zhao
Folded RNAs of unique topology are identified as the structural basis of biological functions and viral diseases. My work aims to resolve the folding of functional RNAs and the mechanical properties at the single molecule level using optical tweezers. Prospective findings may help understand the relations between the mechanical properties of RNA folds and the functions, contributing to the development of anti-viral drugs.
Graduate Students
Noel Hoffer
NINT 2-023A





I study transition paths, the physical trajectories taken by molecules as they traverse the free energy barrier separating reactants and products during chemical reactions.
Matthew Halma




I am working on the dynamic characterization of RNA pseudoknot structures implicated in programmed ribosomal frameshifting, a mechanism often utilized by viruses to regulate gene expression.
Shubhadeep Patra
My research focus is on the study of interactions between Prion protein and anti-prion compounds for understanding the mechanisms of action such as changes in energy landscape, barrier height and location, rates, number and properties of intermediates.
Aaron Lyons
My research focuses on the statistical characterization and analysis of single-molecule force spectroscopy data.
Research Assistants & Undergraduate Students:
Andrew Pyo
My work is on the numerical analysis of DNA transition paths.
Tracy Tan