Some antibodies react best at 37°C (warm antibodies), and some react best at 4°C (cold antibodies). Cold antibodies may only react at 4°C, or they may have a higher thermal range and react at 15°C, 22°C, or even 37°C. For warm antibodies, temperature affects the speed of the reaction, e.g., a warm antibody may take 4 hours to react at 4°C, but only 30 minutes to react at 37°C.
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