1° Immune Response
|
2° Immune Response
|
Note: The crossmatch attempts to prevent a 2° immune response by detecting any antibody present, and then ensuring that only antigen-negative red cells are transfused. It cannot prevent a 1° immune response because only autologous red cells or red cells from an identical twin will introduce no foreign antigens into a person being transfused.
In blood banking, a 1° immune response doesn't always cause mainly IgM antibody to be produced. Sometimes only IgG antibody can be detected (e.g., for antibodies in the Duffy or Kidd systems). Similarly, a 2° immune response does not always cause mainly IgG antibody to be produced. Sometimes, only IgM antibody is produced (e.g., for antibodies in the MN or Lewis systems).
Primary and Secondary Immune Responses |