UA-120290038-1 Cellular Pathways and PM | CHILDREN'S ENVIRONMENTAL HEALTH | AOV

Cellular Pathways and PM

Cellular pathways involved in particulate matter induced DNA alterations

This is experimental in vitro project exploring how particulate matter (PM) components determine activation of cellular pathways leading to DNA damage. PM is the principal urban pollutant linked to various health effects, from increased mortality to cancer. The cellular mechanisms involved in such a wide range of harmful health effects are currently under study.

We have previously reported that PM components trigger differential cellular pro-inflammatory responses depending on the concentration of PM components. This suggests that specific PM components could trigger particular health outcomes. For example, cardiovascular effects have been associated with particle number concentration, whereas respiratory outcomes with PM content of sodium and ammonium nitrate, sulphate, chloride, and organic carbon.

We are studying the mechanisms involved in PM-induced DNA damage and the pro-inflammatory cell responses to DNA.

A Osornio Vargas 2019