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Our Lab Research
Research in our lab is
focused on two specific areas:
1. Understanding (i) how the inflammatory reaction
modulates the AHR-regulated genes, and (ii) the role of coregulatory (coactivator
and corepressor) proteins and the interaction between inflammation and the
AHR in the regulation of AHR-regulated genes. These studies will a)
increase our knowledge about the regulation of the AHR-regulated genes
during inflammation and shall detail the signalling pathways and
mechanisms underlying the modulation of the AHR-regulated genes, and b)
provide information that will make drug usage safer by decreasing the
incidence of adverse effects. This will help to diminish health care
costs, as well as to design strategies that improve treatment of
inflammation-dependent illnesses and disorders.
CYP1A1 Induction 
2. Understanding (i) the potential interaction between
heavy metals and AHR ligands which are common in the environment on the
regulation of AHR-regulated genes, and (ii) investigate the effects of AHR
ligand/metal mixtures on AHR ligands-mediated mutagenicity and
carcinogenicity. These studies will a) increase our knowledge about the
effect of heavy metals on the AHR-regulated genes, and b) provide the
information that will help to design strategies to improve treatment of
AHR ligands mediated mutagenicity and carcinogenicity.
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